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| Interactions: | Methotrexate Adverse Effect decreased methotrexate antineoplastic activity Clinical Management Administer asparaginase nine to ten days before methotrexate therapy or shortly after methotrexate therapy.
Prednisolone Adverse Effect an increased risk of asparaginase toxicity Clinical Management Administer asparaginase after prednisolone rather than before or concurrently to avoid an increased risk of toxicity.
Vincristine Adverse Effect an increased risk of toxicity Clinical Management Administer asparaginase after vincristine rather than before or concurrently to avoid an increased risk of toxicity. |
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